I mention TV Characters as opposed to movie characters as I feel you get a deeper look into the characters over the seasons than a 2 hour movie (well if the show is good that is ).
Here's some of mine (in no particular order):
The Simpsons/Homer Simpson (Dan Castellaneta)
Deadwood/Al Swearengen (Ian McShane)
Dead Like Me/Georgia 'George' Lass (Ellen Muth)
Six Feet Under/Nate Fisher (Peter Krause)
Stargate SG-1/Jack O'Neill (Richard Dean Anderson)