England will field an unfamiliar line-up when they take on USA at Soldier Field, Chicago, live on Sky Sports 1.
Sven Goran Eriksson has taken his side on a much-criticised tour of the United States but will look to learn more about several of his squad players.
Manchester City goalkeeper David James is desperate to prove he is worthy of displacing Paul Robinson and starts as reward for his attitude since being dropped from the team.
With Gary Neville, Rio Ferdinand and John Terry all missing, the back four is likely to include Ashley Cole, Wes Brown, captain Sol Campbell and either Glen Johnson or Phil Neville at right back.
With David Beckham and Owen Hargreaves not available until the friendly with Colombia, the likes of Joe Cole, Michael Carrick and Jermaine Jenas will all expect to start with Alan Smith and Phil Neville candidates for the fourth midfield slot.
If Smith does not play up front, Peter Crouch and Andy Johnson should compete to partner Tottenham's Jermain Defoe.
With Robert Green, Scott Carson, Kieran Richardson and Zat Knight all hoping for debuts, like Crouch, there are plenty of opportunities for new caps.
USA coach Bruce Arena has replaced injury victim Pablo Mastroeni with Kerry Zavagnin of Kansa City Wizards.
Fulham striker Brian McBride is expected to lead the line for the Americans and several other English-based players could be involved including Bobby Convey, Carlos Bocanegra and Marcus Hahnemann.
One man to watch out for is FC Dallas striker Eddie Johnson, who has trained with Manchester United, while Landon Donovan provides a lot of experience in midfield.
Arena has a tough choice in goal with Hahnemann competing with Borussia Monchengladbach's Kasey Keller and Zach Thornton of Chicago Fire, who must be keen to play on his home ground.