FreeSurfer's obviously the best. Not only is it a great pop-up blocker, it "locks" your homepage, so hackers can't change it to some porn website. And while you're at it download Fresh Download, which is the best download manager.
But the thing I hate about pop-up blockers, is say you went here:
http://spiderman.sonypictures.com/
It would block the main website's flash window, so from time to time, you have to create exceptions to some pop-ups.