My brother's computer used to lock up and stuff when it tried to load up thumbnails of movies and stuff, switching to list view helped there.
If it isn't a virus you could try and do that, to see if something happens when windows tries to preview stuff.
I'd say it's a virus, tho', never heard of problem exactly like yours. Did you make sure you formatted all drives in there properly?
But just in case it's a weird case of northbridge-overheating (can cause file-corruption, tho' I never heard of it doing something this specific) or something: check the cooling on your mobo, if there's a small fan on top of the northridge, make sure it spins. Also try running memtest, bad sticks of memory can cause data-corruption.
Also make sure that the drive itself is ok.
Might as well try some weird stuff, if you made absolutely certain it wasn't a virus or a hacker.
And did you install anything weird before it started doing this?
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