The best anti-virus at the moment

[wipe]

AVG, and no complains with ZoneAlarm

[AkaiDoresu]

Norton AntiVirus is the most accurate one at this moment . However it take a lot of memory and have those annoying live updates ;p

Kaspersky I guess a good choice also.

[kenamp]

using avg but after reading thru i might give nod 32 a try. thanks everyone

[MajorDork]

Kaspersky is running smooth right now

[sounder]

Kaspersky
NOD32

[ulun64]

I'm using NOD32 now.

[greken24]

Nod32 Ftw!!

[Demigod]

One more vote for NOD32.

[fruityloop]

Nod32

[Chewie]

I dont use one, EVER i never have viruses because i know what websites are fishy and not, you only get a virus if you are very stupid.- viruses dont come to you,

Very stupid? I would prefer ignorant of the dangers.
Viruses do come to you; in emails and drive-by web downloads. You don't have to go to a pr0n or crack site to pick up these things - KIS occasionally warns me of nasty code on all sorts of sites.
Moreover, how do people know which antispyware and antivirus programs are safe to use? There are far too many malicious spoof programs out there.

pc-cillin picks up stuff no other does and partinered with vista

That guarantees nothing. I remember Adaptec building XP's inbuilt CD burning capability for Microsoft then the next release of their Easy CD Creator rendered XP unbootable.

Norton FTW! I use the Internet security package . Cant beat it .

Norton AntiVirus is the most accurate one at this moment . However it take a lot of memory and have those annoying live updates ;p

You'll be pleased to find out that last week I removed a MicroBillingSystems infection from a computer with a fully up-to-date and running legit copy of NIS2007.
I also had to make a rule to tell it to let Windows Time update itself and set a different NNTP server since NIS had blocked both for some reason.
There is only one advantage that NIS has over Kaspersky and that's the automatic handling of detected threats. I would've installed KIS on that machine if I thought they could make the right decision for its popups.

To all:
NOD32 holds the virusbulletin detection mantle - 100% for so long that I can't remember when it didn't score maximum.
You could do a lot worse if you install Outpost Firewall with it.
If you prefer an integrated AV & firewall, go for Kaspersky Internet Security.
If you want free, Avast appears the most effective AV solution.