I've been using the MX1000 for the last few years and agree with lynx...the shape, once the initial shock wears off, is very comfortable.
It's laser recently died so I'm temporarily using an old school MS mouse and my hand almost cramps gripping the way smaller mousebody.
I love the "clickless" and side-to-side scroll as well (MS makes some units that are pretty ergonomically slick in this area as well) and will definitely look for those features when I go shopping (yup...actual shopping- all of the interface devices-keyboards, mice and monitors I want to see/use in person and don't mind paying a bit of a premium for the privilege).
I'm not a gamer so I can't comment on the impact such a design might have on pixellated mayhem.
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