If you think about it logically, it is easy.
In most cases you need to install the motherboard drivers after you've installed windows. That being the case it obviously means that the system will run without them, even if some devices don't work.
This means that you should be able to uninstall the motherboard drivers and get back to that initial state. Once you've done that, simply replace the motherboard, install the drivers for the new motherboard and you are good to go.
Just remember to make sure that the drivers for the new motherboard are on a device that will still work once you've uninstalled the old motherboard drivers.
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