Page 34 of 41 FirstFirst ... 2431323334353637 ... LastLast
Results 331 to 340 of 410

Thread: I think I know what's up with Idol.

  1. #331
    IdolEyes787's Avatar Persona non grata
    Join Date
    Feb 2008
    Location
    State of Grace
    Posts
    31,313
    Mechanism of toxicity



    The compound readily eliminates a chloride ion by intramolecular nucleophilic substitution to form a cyclic sulfonium ion. This very reactive intermediate tends to permanently alkylate the guanine nucleotide in DNA strands, which prevents cellular division and generally leads directly to programmed cell death or, if cell death is not immediate, the damaged DNA may lead to the development of cancer Sulfur mustard is not very soluble in water but is very soluble in fat, contributing to its rapid absorption into the skin.
    400px-Mustard-dna.png

    In the wider sense, compounds with the structural element BCH2CH2X, where X is any leaving group and B is a Lewis base are known as mustards. Such compounds can form cyclic "onium" ions (sulfonium, ammoniums, etc.) that are goodalkylating agents. Examples are bis(2-chloroethyl)ether, the (2-haloethyl)amines (nitrogen mustards), and sulfur sesquimustard, which has two α-chloroethyl thioether groups (ClH2C-CH2-S-) connected by an ethylene (-CH2CH2-) group. These compounds have a similar ability to alkylate DNA, but their physical properties, e.g. melting point, vary.


    Mary would probably have an orgasm were he to read this.
    Respect my lack of authority.

  2. Lounge   -   #332
    manker's Avatar effendi
    Join Date
    May 2004
    Location
    I wear an Even Steven wit
    Posts
    32,371
    Pretty sure Mary doesn't like orgasms. She just likes looking at pretty girls.

    also, I preferred mbm's c&p about jamie oliver being a spacker.
    I plan on beating him to death with his kids. I'll use them as a bludgeon on his face. -

    --Good for them if they survive.

  3. Lounge   -   #333
    mjmacky's Avatar an alchemist?
    Join Date
    May 2010
    Posts
    10,809
    Rather I think Idol was calling out to me due to my absence in this thread, at least that's how I was approaching the excerpt. At first I thought I was reading about an aggressive chemotherapy technique until I saw that it alkylates guanine indiscriminately, then thinking, "what are they trying to do, kill people?". I finally reached the later portion of it and realized it was describing the mechanism by which mustard gas is harmful. Did any of you, any at all, bother to read it? I won't say that it's poorly written, but it could be much improved.

    I carry two lethal weapons in my house, my left elbow and my right knee. I've only handled an unloaded handgun once, after my Texan neighbor's friend accidentally fired a round into his floor (instead of through the drywall leading to my bedroom).
    Everything is brought to you by Fjohürs Lykkewe.

  4. Lounge   -   #334
    manker's Avatar effendi
    Join Date
    May 2004
    Location
    I wear an Even Steven wit
    Posts
    32,371
    Quote Originally Posted by Mary
    I finally reached the later portion of it and realized it was describing the mechanism by which mustard gas is harmful. Did any of you, any at all, bother to read it?
    Didn't have to, I realised that it was a descriptor of the mechanism by which its harmful by the title. It even says toxicity.
    I'm surprised it took you til the latter portion of it to glean this information.

    You know, what with being a chemistry student and all :]
    I plan on beating him to death with his kids. I'll use them as a bludgeon on his face. -

    --Good for them if they survive.

  5. Lounge   -   #335
    megabyteme's Avatar RASPBERRY RIPPLE BT Rep: +19BT Rep +19BT Rep +19BT Rep +19
    Join Date
    Apr 2009
    Location
    Using Mrs. Nussbaum's CC#
    Posts
    17,943
    I can see I'm in hostile territory. I label you all terrorists, and will shoot on site. In fact, I fired a warning shot at my monitor. It grazed my son's head, but luckily he's already retarded, so no real damage done.

    BTW, Where's skiz when I need him?
    Quote Originally Posted by IdolEyes787 View Post
    Ghey lumberjacks, wolverines, blackflies in the summer, polar bears in the winter, that's basically Canada in a nutshell.

  6. Lounge   -   #336
    mjmacky's Avatar an alchemist?
    Join Date
    May 2010
    Posts
    10,809
    Quote Originally Posted by manker View Post
    You know, what with being a chemistry student and all :]
    My eyes are drawn to figures, I don't have to be elitist every time.
    Everything is brought to you by Fjohürs Lykkewe.

  7. Lounge   -   #337
    manker's Avatar effendi
    Join Date
    May 2004
    Location
    I wear an Even Steven wit
    Posts
    32,371
    Skizo is out hunting for deer to shoot and then decapitate.

    I've never quite got over seeing that pic.
    Not saying it made me go all Idol but just the sheer pointlessness of the head in a bucket.
    I plan on beating him to death with his kids. I'll use them as a bludgeon on his face. -

    --Good for them if they survive.

  8. Lounge   -   #338
    manker's Avatar effendi
    Join Date
    May 2004
    Location
    I wear an Even Steven wit
    Posts
    32,371
    Quote Originally Posted by mjmacky View Post
    Quote Originally Posted by manker View Post
    You know, what with being a chemistry student and all :]
    My eyes are drawn to figures, I don't have to be elitist every time.
    That's the beauty of being one of the cognoscenti. You don't have to be, it's an elephant and it's in the room yet your associates don't let it diminish your relationship with them. Not if you do it correctly.

    You'll learn this, one day, when you pass your exams and get a job and get promoted to auspiciousness.
    I plan on beating him to death with his kids. I'll use them as a bludgeon on his face. -

    --Good for them if they survive.

  9. Lounge   -   #339
    IdolEyes787's Avatar Persona non grata
    Join Date
    Feb 2008
    Location
    State of Grace
    Posts
    31,313
    Quote Originally Posted by manker View Post
    Skizo is out hunting for deer to shoot and then decapitate.

    I've never quite got over seeing that pic.
    Not saying it made me go all Idol but just the sheer pointlessness of the head in a bucket.
    Too many Texans.Too many guns.Too few things that make our eyes light up with child-like wonder at their grace and beauty..
    Respect my lack of authority.

  10. Lounge   -   #340
    mjmacky's Avatar an alchemist?
    Join Date
    May 2010
    Posts
    10,809
    Quote Originally Posted by manker View Post
    You'll learn this, one day, when you pass your exams and get a job and get promoted to auspiciousness.
    The mundanity of your presentation made me want to commit suicide.
    Everything is brought to you by Fjohürs Lykkewe.

Page 34 of 41 FirstFirst ... 2431323334353637 ... LastLast

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •