Assuming you are going for one of the Asus boards, you have 4 options:
A8N-SLI Deluxe $175
A8N-SLI $160
A8V-E Deluxe $145
A8N-E $125
I can see no advantages of the A8V-E Deluxe over the A8N-E, so I would drop that from the list straight away.
Do you need SLI?
Translate that question into "Will you ever but 2 identical SLI enabled graphics cards for the same system?". Remember that it is unlikely that buying a second card a few months later will be sufficiently similar to allow the 2 cards to successfully co-exist. So if you buy 1 now you will have to buy 2 more later and get rid of the one you have.
Only you can answer that question. If the answer is no then stop looking at the SLI boards.
Other questions are:
how many SATA drives are you likely to buy; I suspect the answer will be 1 or at most 2.
how many gigabit ethernet ports are you likely to need; I suspect the answer will be 1.
If so, even if you go for the SLI board you don't need the Deluxe.
The same rules apply with boards from other manufacturers - perform the same analysis. Don't buy what you will never use unless it is part of a package with something that you feel is a "must have". Otherwise you are simply wasting money.
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