Leave the jumpers.
When you start the computer for first time the board will autodetect the right speeds for your CPU. (FSB and MULTIPLIER)
To get dual channel read the manual for your board. Usually there is a certain 2 slots you must put the ram into to get it working in dual chanel mode.
Be careful when putting the heatsink on the board. Don't slip with the screwdriver or anything. Also make sure you put it on right. If for any reason you need to remove the heatsink then you will need to buy new thermal paste and apply it.
edit: you should also make sure to use the spacers (pic below) and make sure they are aligned correctly. I didn't use them the first time I installed my motherboard and it fried
Spacers attach to the case where the motherboard is going to sit...they line up where the screws on the motherboard are going to be. The spacers have threads on the inside for the motherboard mounting screws to go into.
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